Ramesh Singh#, Krupa Kansara#, Pankaj Yadav, Abdulkhalik Mansuri, Ashutosh Kumar, Dhiraj Bhatia, ACS Appl. Nano Mater. 2023, 6, 14, 13443–13452. https://doi.org/10.1021/acsanm.3c02029 (#Authors contributed equally)
Ramesh Singh#, Krupa Kansara#, Pankaj Yadav, Abdulkhalik Mansuri, Ashutosh Kumar, Dhiraj Bhatia, ACS Appl. Nano Mater. 2023, 6, 14, 13443–13452. https://doi.org/10.1021/acsanm.3c02029 (#Authors contributed equally)
R. Singh*, P. Yadav, H. Naveena A and D. Bhatia* Nanoscale 2022, https://doi.org/10.1039/D2NR05749B
K. Kesharwani, R. Singh, N. Kumar, N. Singh, P. Gupta, K. B. Joshi, Nanoscale 2022, 14, 10200–10210. https://doi.org/10.1039/D2NR01524B
We architect a C3-symmetric triskelion “Nanotorus” structures into hierarchic andorganized “Microtorus” structures by using mercury, a toxic metal. Thus in this study wehave demonstrated a unique example of toxic metal instructed assembly for“Nanoarchitectonics” of the formation of microtorus structures, which can be exploited forseveral potential applications ranging from biomedical to nanotechnology.
R. Singh#, N. Singh#, S. Sharma#, S. Rajput#, N. Chattopadhyay, D. Tewari, K. B. Joshi, S. Verma, Chem. Sci. 2021, 12, 16085-16091. https://doi.org/10.1039/D1SC04030H (#Authors contributed equally)
Hydrogen sulfide Sensing Naphthalimide based Peptide conjugate (HSNPc) worked as novel cancer cell imaging agent and showed selective cell apoptosis.
R. Singh, M. J. Khan, J. Rane, A. Gajbhiye, V. Vinayak, K. B. Joshi, ChemistrySelect 2020, 5, 3091 –3097. https://doi.org/10.1002/slct.201904248
Facile and effective fabrications of diatom with Tyr- ZnII conjugate lead special class of highly biocompatible diatom-microcontainers. Such microcontainers have superior control for the delivery of toxic metal ions hence provide less physical damage and consequently found responsive against clinically relevant bacteria.
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R. Singh, N. K. Mishra, P. Gupta, K. B. Joshi, Chem. Asian J. 2020, 15, 531–539. https://doi.org/10.1002/asia.201901715
The fine tuning of aromatic residues of a designed short peptide amphiphile leads to a pair of constitutional isomers. Interestingly, in the presence of copper metal ions, one of the isomer self-assembled into vertically stacked terraced layers with decreasing size that resemble to nanodome-like structures.
R. Singh, N. K. Mishra, N. Singh, P. Rawal, P. Gupta, K. B. Joshi, New J. Chem. 2020, 44, 9255–9263. https://doi.org/10.1039/D0NJ01501F
Transition metal ions mediated secondary structural transformation of di-phenylalanine based short peptide amphiphile can pave a way to design and develop the stimuli responsive nanomaterials for various plausible applications.
R. Singh, V. Suryavashi, V. Vinayak, K. B. Joshi, ChemistrySelect 2019, 4, 5810-5816. https://doi.org/10.1002/slct.201900847
Structurally constraints Pro-Pro dipeptide in the presence of Gold ion self assembled into multi-shaped sheet like structures. These hybrid structures worked as toxic metal ions reservoirs and platform to target bacterial membrane therefore have shown great potential to treat the bacterial infections.
R. Singh#, S. Gupta#, V. Kumar, P. Shukla, K. B. Joshi, Chem. Asian J. 2018, 13, 3285–3295. https://doi.org/10.1002/asia.201801270 (#Authors contributed equally)
As good as gold: We report the formation of gold nanoparticle (AuNP)–biotinylated triskelion peptide hybrid nanostructures by using self-organization and mimicking strategies to develop AuNP-ornamented peptide nanobangles with predetermined properties on biocompatible surfaces.
R. Singh, N. K. Mishra, V. Kumar, V. Vinayak, and K. B. Joshi, ChemBioChem. 2018, 19, 1630-1637. https://doi.org/10.1002/cbic.201800220 Very Important Paper (VIP) Media Cover Chemistry View
Biomolecular switches: A palmitoylated bis-tyrosine-based short-peptide amphiphile (sPA) transforms its morphology in the presence of bioactive transition-metal ions. The metal-ion-conjugated sPA hybrid nanostructures were effective against Gram-positive bacteria. It was found that the designed sPA was greatly taken up by bacteria and therefore acted as a cytotoxic metal ion delivery agent.
R. Singh#, V. Kumar#, K. B. Joshi, New J. Chem. 2018, 42, 3452-3458. https://doi.org/10.1039/C7NJ04248E (#Authors contributed equally)
Triskelion biotinylated peptide get self assembled into robust nanotorus like structures which further lead to nanotorus dimer and chain of nanotorus by using natural principles of receptor- ligand recognitions properties of biotin avidin interaction.
R. Singh, S. Gupta, V. Kumar, K. B. Joshi, ChemNanoMat 2017, 3, 620-624. https://doi.org/10.1002/cnma.201700129
The self-assembly of the helix-initiating dipeptide Pro-Pro has been investigated. In the absence of CuII ions the dipeptide self-assembled into micrometer-sized three-dimensional dumbbells. Furthermore, the presence of CuII ions triggered the dumbbells to form into robust 3D radial disc structures, which could be of great interest for several biotechnological applications.